Another genetic disorder involving AVMs is capillary malformation–arteriovenous malformation (CM-AVM) syndrome, which follows an autosomal dominant inheritance pattern due to loss of function variants in RAS P21 Protein Activator 1 (RASA1) and Ephrin Receptor B4 (EPHB4)] [131,132]. This evidence concerns the gene RASA1 and capillary malformation-arteriovenous malformation syndrome.