The Nomenclature Committee on Cell Death and numerous other pioneering cancer/p53 biologists use the terms “apoptosis” and “cell death” interchangeably, disregard the mind-numbing complexity and heterogeneity that exists within a tumor (intratumor heterogeneity), disregard the contribution of polyploid giant cancer cells (PGCCs; the root causes of therapy resistance and relapse) to this heterogeneity, and then propose novel apoptosis-stimulating anticancer strategies. This evidence concerns the gene TP53 and cancer.