Figure 4 presents gene expression relative to the control (sham irradiation/standard diet). At 28 weeks after neonatal X-irradiation, the increase in Adm2 and Vnn1 mRNA levels and the decrease in Crtac1 mRNA expression continued. In thyroid tumors induced by IDD, the expression of every identified gene was significantly changed. The increase in Vnn1 and the decrease in Crtac1 were further enhanced by the combination of X-irradiation and IDD (1w12Gy + IDD group). This evidence concerns the gene CRTAC1 and thyroid tumor.