IL1B and systemic-onset juvenile idiopathic arthritis: For instance, Still’s disease is an infrequent hyper-cytokinemic syndrome characterized by fever, skin rash, generalized lymphoid hyperplasia, thrombocytosis, and huge levels of ferritin; it also exhibits life-threatening complications such as macrophage activation syndrome and chronic lung disease, for which IL-1 inhibition has shown the highest therapeutic efficacy [24].