RARRES2 and ovarian carcinoma: Moreover, studies conducted on ovarian cancer cell lines have demonstrated that chemerin initiates the CMKLR1/Ras homolog family member A (RhoA)/rho-associated, coiled-coil-containing protein kinase 1 (ROCK) cascade, which contributes to the migration and epithelial–mesenchymal transition (EMT) of ovarian cancer cells [39].