Genetic and genome-wide association studies have identified the participation of FcγR in the physiopathology of a wide variety of autoimmune diseases such as SLE [69,138], rheumatoid arthritis [139,140,141], celiac disease [140,142], and inflammatory metabolic diseases such as cardiovascular disease [143] and diabetes mellitus [140]. This evidence concerns the gene FCGR2A and systemic lupus erythematosus.