Oxidative stress is thought to be an early and central contributor to the pathogenesis of PSP, CBD, and other 4R tauopathies [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18], yet we currently lack reliable methods for detecting and tracking tau-associated oxidative stress in vivo. Here, MAPT is linked to tauopathy.