A study utilizing in vitro colony formation assays with HCC cell lines, xenograft tumor models, comet assays, cell cycle flow cytometry, γH2AX foci detection, chromatin fractionation, and immunofluorescence staining presented that UBE2T mediates H2AX/γH2AX mono-ubiquitination, maintains checkpoint kinase 1 (CHK1) activation, and provides sufficient time for radiation-induced DNA repair to confer radioresistance in HCC [26]. The gene discussed is CHEK1; the disease is hepatocellular carcinoma.