Researchers using miRNA database screening and RNA sequencing analyses revealed that miR-138-5p enhances the radiosensitivity of HCC by inhibiting EZH2 expression, downregulating H3K27me3 levels, and suppressing the HIF-1 signaling pathway, which collectively reduces cell migration, invasion, and epithelial–mesenchymal transition [63]. This evidence concerns the gene HIF1A and hepatocellular carcinoma.