MIR22HG and hepatocellular carcinoma: Furthermore, through gene microarray screening of radiation sensitivity-related genes, combined with in vitro irradiation of HCC cells (HepG2 and MHCC97H), real-time PCR, and Western blot analyses, researchers identified that miR-22-5p promotes MIR22HG promoter histone acetylation by suppressing HDAC2 expression, which leads to the upregulation of MIR22HG expression and ultimately enhances HCC radiosensitivity [65].