We used logistic regression analysis to assess the investigation between rs8140110 and DN after adjusting for the waist duration of type 2 diabetes mellitus, duration of hypertension, systolic blood pressure, waist circumference, diabetic retinopathy, diabetic neuropathy, HbA1c, fasting glucose, urea, creatinine, cystatin C, and urine albumin–creatinine ratio. This evidence concerns the gene CST3 and diabetic neuropathy.