We used logistic regression analysis to assess the investigation between rs8140110 and DN after adjusting for the waist duration of type 2 diabetes mellitus, duration of hypertension, systolic blood pressure, waist circumference, diabetic retinopathy, diabetic neuropathy, HbA1c, fasting glucose, urea, creatinine, cystatin C, and urine albumin–creatinine ratio. The gene discussed is CST3; the disease is Hypertension.