PANX1 and major depressive disorder: In the all subjects analysis, PANX1 mRNA expression in the white matter was significantly higher in the MDD-S compared to CTL subjects (ANCOVA: F(2,22) = 5.86, p = 0.02, after controlling for the effect of PMI, Figure 3), with a significant main effect of disease observed (two-way ANOVA: F(2,14) = 4.96, p = 0.02, Figure 1I).