In an assessment of the effect of antidepressant medication on the purinergic transcript expression in MDD-NS and MDD-S subjects combined (MDD) in the superficial gray matter, ADORA2A mRNA expression was significantly greater in MDD subjects off compared to on medication (Welch’s-corrected t = 2.16, p = 0.001, Figure 4A). The gene discussed is ADORA2A; the disease is major depressive disorder.