Among the purinergic P2Y receptors, P2RY12 mRNA expression was significantly greater in the MDD-S compared to the MDD-NS all subjects group in the white matter, with a significant main effect of disease observed (two-way ANOVA: F(2,14) = 5.82, p = 0.01, Figure 1F). This evidence concerns the gene P2RY12 and major depressive disorder.