PANX1 mRNA expression was significantly greater in the MDD-S compared to MDD-NS female subjects in the superficial gray matter (one-way ANOVA: F(2,10) = 4.66, p = 0.05, Figure 2G) and white matter (ANCOVA: F(2,9) = 13.96, p = 0.03, after controlling for the effect of PMI, Figure 2I). This evidence concerns the gene PANX1 and major depressive disorder.