Extracellular ATP Catabolic Transcripts: In the all subjects group, ENTPD2 mRNA expression was significantly lower in the MDD-S compared to MDD-NS subjects in the deep gray matter (two-way ANOVA: F(9,13) = 1.27 (sex effect), F(2,13) = 3.61 (disease effect) p = 0.05, Figure 2B). The gene discussed is ENTPD2; the disease is major depressive disorder.