CDKN2A and obstructive sleep apnea syndrome: We further identified that IH promotes increased expression of p16, a senescence marker, and that the effect of IH appears to be equivalent to 80 weeks of normoxic life (96 weeks in RA minus 16 weeks in IH), further corroborating the previous observations that untreated OSA is associated with an increase in biological aging markers [28,33].