Overexpression of talins, integrins, and other adhesion-related proteins can mimic some part of the integrin-based ECM adhesion-signaling in circulating tumor cells (Figure 1A Dissemination), promoting FAK activation and its downstream effectors, inducing cell survival and resistance to anoikis (programmed cell death resulting from detachment from the ECM) [60,135,136,137]. The gene discussed is PTK2; the disease is neoplasm.