Measurement of inflammatory biomarkers, such TNF-α, IL-1β, IL-6, IL-8, IL-17, IFN-γ, IL-10, IL-4, Il-13, TGF-β, VEGF EGF, HGF, BDNF, MMP-9, CRP, microplastics, and selected parameters of oxidative stress, should be carried out in the context of psychiatric evaluations, taking into account the possible overlap between changes in immune and inflammatory responses in smokers, addiction disorders, and other psychiatric diseases [236]. Here, IL6 is linked to psychiatric disorder.