For the heart, lactate is an important metabolite for the prevention of CVD by promoting angiogenesis through pro-angiogenic NF-kB/IL-8 signaling in order to ameliorate ischemia and hypoxia [147], which contribute to the maintenance of cardiovascular function in patients with myocardial infarction (MI), ischemic cardiomyopathy, and other CVDs [148,149]. The gene discussed is NFKB1; the disease is myocardial infarction.