Previously, we have demonstrated that FA acts as an antagonist of PXR in the treatment of APAP hepatotoxicity, and the level of ER stress was significantly decreased in the FA-treated model group, and combined with the above results, we conclude that FA regulates ER stress by affecting the level of PXR, which subsequently attenuates liver injury. This evidence concerns the gene NR1I2 and autoimmune pulmonary alveolar proteinosis.