Xu et al. (2020) reported that high-dose Se alleviated pancreatic injury via Nrf2/NQO1/HO-1 upregulation in acute pancreatitis models [18], whereas NJSPd−1’s suppression of Nrf2 under high glucose suggests a tailored mechanism for chronic metabolic disorders. This evidence concerns the gene NQO1 and acute pancreatitis.