PARP1 and pancreatic neoplasm: Although the inhibition or the genetic deletion of PARP1 did not prevent cytotoxicity of Ph-Asc on pancreatic cancer cells, suggesting that it was DNA damage and not the disruption of cellular bioenergetics that was the predominant factor for the anticancer activity of Ph-Asc [22], we aimed to investigate the effect of Ph-Asc and the other two investigated compounds (CQ and resveratrol) on the bioenergetics status (cellular level of NAD+ and ATP) of pancreatic cancer cells.