Here, we observed that in age-related neurodegeneration models, 27-HMA delayed paralysis in AD nematodes CL4176 and CL2120 rescued the impaired motor ability of 6-OHDA-treated PD nematodes UA57 and alleviated the α-synuclein deposition in nematodes NL5901, suggesting that 27-HMA may also improve the pathogenesis and behaviors of AD and PD nematodes. Here, SNCA is linked to Alzheimer disease.