The results of immunohistochemistry (Figure 7A) and quantitative ELISA (Figure 7B,C) showed that the levels of IL-1β and TNF-α in the Apo-Ce/Mn group were significantly lower than those in the control group and the PEG-Ce/Mn group, and the results of ELISA (Figure 7D) showed that the level of MCP-1 was the lowest in the Apo-Ce/Mn group, which indicated that Apo-Ce/Mn had potent anti-inflammatory effects for the treatment of atherosclerosis. This evidence concerns the gene AOPEP and atherosclerosis.