More importantly, supplementation with SeY was found to inhibit the NF-κB and MAPK signaling pathways further, leading to the downregulation of proinflammatory cytokines and DEFB2 to control inflammation in a goat endometritis model under high cortisol background, which was consistent with the in vitro study of BEECs [19]. This evidence concerns the gene NFKB1 and endometritis.