HP and endometritis: In an observational study, we recently evaluated the spontaneous P4 profiles from 35 to 70 DIM in postpartum cows that had indications of both systemic inflammation in the first week postpartum (serum HP ≥ 0.8 g/L) and endometritis (≥6% endometrial PMN) at 35 DIM compared to healthy cows [98].