SIX1 and neoplasm: miR-30b can inhibit the PI3K/AKT (phosphoinositide 3-kinase/protein kinase B) signaling pathway through the regulation of EGFR, AKT, Derlin-1, GNA13), SIX1, and other target genes, thus inhibiting the epithelial–mesenchymal transition process of tumor cells and promoting apoptosis [78].