IL1B and Infertility: In addition, it has been shown that TPP could be beneficial in the treatment of cyclophosphamide-induced ovarian injury and infertility [22] since the administration of 25 mg/kg of TPP intraperitoneally in the anterior abdomen in rats (one dose) decreases the levels of the oxidant malondialdehyde (MDA), proinflammatory nuclear factor kappa B (NF-κB), tumor necrosis factor alpha (TNF-α), and interleukin 1 beta (IL-1β); in addition, it reduces severe histopathological damage associated with cyclophosphamide in ovarian tissue [22].