The results of the receiver operating characteristic (ROC) analysis to distinguish the acute phase showed that PYY could not be used for diagnosis (p: 0.066), but asprosin was associated with the acute phase of schizophrenia (p < 0.001) and both asprosin and PYY were associated with the disease (p < 0.001, p < 0.001). The gene discussed is PYY; the disease is schizophrenia.