A study by Kim in 2011 examined the expression levels of C-reactive protein (CRP), matrix metalloproteinase-14 (MMP-14), and the tissue inhibitor of metalloproteinases-2 (TIMP-2) in gingival tissues from individuals with chronic periodontitis, characterized by inflammation and alveolar bone resorption, both with and without type 2 diabetes mellitus (DM). This evidence concerns the gene TIMP2 and chronic periodontitis.