Subsequently, TBX20 mutational screening investigations expanded the clinical phenotypic spectrum linked to deleterious TBX20 mutations, including the double-outlet right ventricle, Fallot’s tetralogy/pentalogy, patent ductus arteriosus, common atrioventricular canals, aortic coarctation, and persistent truncus arteriosus, and these investigations unveiled more TBX20 mutations contributing to CHD [64,65,66,67]. The gene discussed is TBX20; the disease is persistent truncus arteriosus.