A truncating titin mutation is the most frequent mutation (13% and 25% of non-familial and familial cases of DCM, respectively [85]) and desmoplakin (DSP), filamin C (FLCN), lamin A/C (LMNA), phospholamban (PLN), and RNA binding motif protein 20 (RMB20) mutations are strong predictors of sudden cardiac death (SCD) [75]. This evidence concerns the gene DSP and familial dilated cardiomyopathy.