A combination of the parameters’ apparent diffusion coefficient (ADC) and fractional volume of extravascular extracellular space (ve) revealed the best prediction of IDH mutant vs. wildtype gliomas (AUC = 0.976 (0.943–1.000)) and astrocytomas vs. oligodendrogliomas (AUC = 0.840 (0.645–1.000)) with the lowest Akaike information criterion. The gene discussed is IDH1; the disease is astrocytoma (excluding glioblastoma).