Previous studies have already shown that combined approaches of DKI and DCE-MRI lead to a better differentiation between HGG and LGG [20,29,30], IDH mutant and wildtype gliomas [20,30,31], and 1p/19q codeleted and 1p/19q non-codeleted LGG [32], but these studies focused on a central tumor volume. Here, IDH1 is linked to central nervous system cancer.