Moreover, a recent analysis of light-chain variable gene mutational status in CLL identified a significant association between the IGKV1-39/1D-39 rearrangement and NOTCH1 mutations, trisomy 12, unmutated IGHV, and stereotyped subsets 1 and 8 [83]. Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.