PIK3CA and lung carcinoma: Another AI study revealed that lung cancer cell lines which are considered insensitive to the cytotoxic action of the p53 activator Nutlin-3, due to the mTOR and PI3K pathway, were actually highly sensitive to the dual PI3K/mTOR inhibitor NVP-BEZ235, while they did not respond to either the PI3K-specific LY294002 or Bcl-XL-specific 2,3-DCPE [452].