In a study which evaluated the three immune phenotypes of lung cancer—namely, inflamed, immune-excluded, and immune-desert—it was found that KRAS mutation, BRAF mutation, and MET splicing variant were mostly observed in the inflamed sub-type, while EGFR and PIK3CA mutations were the most prominent mutations found in the immune-excluded sub-type [450]. This evidence concerns the gene EGFR and lung cancer.