CD274 and neoplasm: MicroRNAs, which can be obtained through liquid biopsy and analyzed through AI, might be indicative of lung tumors decades before their clinical appearance [368], while multimodal detection of PD-L1 (e.g., through liquid biopsy specimens of PD-L1 protein, PD-L1 mRNA, and circulating PD-L1) might provide a more comprehensive tumor profile and could help to determine those patients who are more suitable for immunotherapy [298]; although the specimen processing technique could limit the accuracy of the method [335].