H&E, Ki67, and cleaved/active caspase-3 staining on one tissue from the vehicle group, DOX group, Doxil group, and SPEDOX-6 treatment group are shown in Figure 5A. By visualizing Figure 5A, two left panels, the vehicle, and DOX treatment group tumor tissues seem to similarly display high cancer cell density with large nuclei and high Ki67 but low cleaved caspase-3 levels. The gene discussed is CASP3; the disease is cancer.