The purpose of this study was to quantitatively compare the diagnostic performance of DKI, NODDI, and DMI parameters in molecular subtype identification according to the WHO 2021 classification of CNS tumors, which divides adult-type gliomas into (i) glioblastomas, Isocitrate dehydrogenase (IDH) wildtype; (ii) astrocytomas, IDH mutant; and (iii) oligodendrogliomas, IDH mutant and 1p/19q-codeleted [2,26,27]. This evidence concerns the gene IDH3A and glioblastoma.