The clinicopathological features are overlapped with those in pediatric non-Down syndrome acute megakaryoblastic leukemia (AMKL), characterized by infant onset, a male predominance, involving PB, BM, and extramedullary organs (such as the liver and spleen), harboring CBFA2T3::GLIS2 or rarely CBFA2T3::GLIS3, and an extremely poor prognosis [35,36,37,38,39]. Here, CBFA2T3 is linked to Down syndrome.