Potential therapeutic approaches include the application of PI3K/AKT/mTOR inhibitors, such as Alpelisib and Everolimus, as well as lactate dehydrogenase inhibitors to diminish lactate production, and buffering agents like bicarbonate to mitigate the acidity of the tumor microenvironment (TME) [146,147,148]. Here, PIK3CA is linked to neoplasm.