Another pathway identified to be enriched in the cancer compartment in PNI but not previously reported as associated with PNI was polyamine regulation (Figure 3b and Table S4), which includes the gene Spermidine–Spermine N1-Acetyltransferase 1 (SAT1), which was up-regulated in cancer cells invading nerves (Figure 3d). This evidence concerns the gene SAT1 and cancer.