HMOX1 and melanoma: In the metastases, CDK4 and DDX11 expression in melanoma cells were significantly higher (Wilcoxon-test p-value < 0.05), and HMOX1 and PAEP expression significantly increased (Wilcoxon-test p-value < 0.05 in both melanoma cells and the stroma/TME), while SCAI expression was significantly increased in the metastatic stroma (Figure 7E).