HMOX1 and melanoma: In addition, spatial expression-based ROC curve analysis followed by Kaplan–Meier (K-M) analysis revealed that higher ADAM10, FGA, DDX11, PAEP, and SCAI expression in primary melanoma cells could be linked to more prolonged survival, as well as a higher stromal expression for ADAM10, CDK4, SCAI, HMOX1, and PAEP (Figure 7D and Figure S6A–C, and Table S9A).