Univariate analysis revealed that subjects with AVP-D were younger and had a higher burden of BRAF V600E pathogenic variants and clinical and biochemical endocrine deficiencies compared to those without AVP-D, such as a higher prevalence of panhypopituitarism, central hypogonadism, and central hypothyroidism and lower urine osmolality and serum IGF-1 levels. This evidence concerns the gene BRAF and hypogonadotropic hypogonadism.