BRAF and hypogonadotropic hypogonadism: In models adjusting for age, sex, and BMI, the BRAF V600 E pathogenic variant [OR (95%CI) 7.38 (1.84 to 39.01)], central hypogonadism [OR (95%CI) 6.19 (1.44 to 34.80)], and primary hypothyroidism [OR (95%CI) 13.89 (1.40 to 406.5)] emerged as being associated with a higher odds of having AVP-D (Table 3).