CD200 and Merkel cell skin cancer: On univariable analysis, we observed that MCC relapse was significantly associated with low CD200 expression in primary tumors (H-score ≤ 77, 25th percentile of CD200 expression, p = 0.0007, HR 9.35, 95% CI 2.56 to 34.17), male sex (p = 0.045, HR 2.41, 95% CI 1.009 to 5.76), and immunosuppression (p = 0.0031, HR 6.36, 95% CI 1.87 to 21.65; Figure 1, Figure 2 and Figure 3).