The “acute GVHD” cluster was defined by an IFN aggregate (A28), inflammation aggregates (A33,35), other aggregates with no known definition (25, 30, 31 and 32), and modules pertaining to the following functions: TNF (in A18), neutrophils/neutrophil activation (in A38), and prostanoids (in A34). The gene discussed is TNF; the disease is acute graft versus host disease.