Loss of H3K27me3, but not DNA methylation, in CAFs was enriched for genes involved in stem cell niches, cell growth, tissue development, and stromal-epithelial interactions, such as WNT5A, GREM1, and IGF2 [41], among which WNT5A was associated with poor prognosis in GC. The gene discussed is WNT5A; the disease is gastric cancer.