Within cancer associated Tertiary Lymphoid Structure (CA-TLS) in the TIME of thyroid cancer (schematically represented with left side panel specimen, CA: cancer, GC: Germinal Center), exhausted CD8+ T cells (orange circle) may downregulate CD8 to become double-negative T cells (DN T, yellow circle) defined as positive for GZMK, low in GZmB, TNFRSF9 (CD137) and PFR1; and high in IL7R, SELL, TCF7 and FasL. The gene discussed is IL7R; the disease is thyroid gland carcinoma.