This BRAFV600E-induced MDSC-mediated immune suppression involves re-activation of the developmental factor T-box transcription factor 3 (TBX3), which in turn, up-regulates C-X-C motif chemokine receptor 2 (CXCR2, a protein that regulates the migration and recruitment of lymphocytes) ligands, in a Toll Receptor 2 (TLR2)-Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) dependent manner, leading to MDSCs recruitment into the tumor microenvironment. Here, TLR2 is linked to neoplasm.