CDKN1A and posterior cortical atrophy: There are also some other known AR signaling pathways mediating cellular senescence in PCa, including p53-p21 [51], p16-pRb-E2F1 [12], BHLHE40-CCNG2 [11], LYL1-p27Kip1 [52], and AR-MIR503HG-miR-424-5p signaling [53] axes that collectively lead to cell cycle arrest and senescence regulation.