AR and posterior cortical atrophy: In combination with ChIP-seq and RNA-seq experiments, the obtained data suggest that H2AJ is a direct AR target gene, being a downstream factor in AR signaling, and partially regulates SAL-induced cellular senescence, promotes the cell growth of CSPC and CRPC cells, and inhibits the expression of mesenchymal markers, which may explain the lower expression of H2AJ in PCa metastasis.