A variety of PI3K/AKT inhibitors are currently under investigation in prostate cancer in combination with other therapies such as ARSIs, docetaxel, bicalutamide, and hydroxychloroquine (NCT06190899, NCT03218826, NCT05348577, NCT01480154, NCT04586270, NCT01251861). This evidence concerns the gene AKT1 and prostate carcinoma.