On the other hand, in HCC patients with cirrhosis, early recurrence unveils aberrantly dominant pathways of HOX genes, FOXO-mediated transcription, p16INK4A-mediated CDK4 and CDK6 regulation, TP53, Wnt/beta-catenin, and Eph/ephrin signaling. This evidence concerns the gene CDK4 and hepatocellular carcinoma.