On the other hand, CRC cells protect themselves from oxidative damage by evading apoptosis and upregulating antioxidant molecules, such as SOD, GPX, thioredoxin/thioredoxin reductase (Trx/TrxR) system and glutathione S-transferases (GSTs) [27,49]. The gene discussed is HPGDS; the disease is colorectal carcinoma.