The results of the present study showed that GluOC increased the expression levels of Nrf2 by activating the PIK3CA/AKT signaling pathway, thereby increasing the expression of SLC7A11 and GPX4 and increasing GSH content in MDA-MB-231 BC cells, promoting TNBC proliferation and metastasis whilst inhibiting ferroptosis. This evidence concerns the gene NFE2L2 and breast cancer.