At final follow-up (median follow-up was 66 months (IQR 34–119)), 25 (40%) of 62 patients with available calcitonin measures were biochemically cured, and 17 (27%) patients were deceased (14/17 sporadic MTCs); 10 (16%) died due to MTC progression (9/10 sporadic MTCs). Here, CALCA is linked to medullary thyroid gland carcinoma.