Additional alterations including reduction in p16INK4B and p130 levels, loss of the tumor suppressor genes CDH11 and p75NTR, and copy number gain and high expression of the oncogenes MYCN, E2F3, DEK, KIF14 and MDM4, can induce clonal expansion and full-blown retinoblastoma [151]. Here, RBL2 is linked to retinoblastoma.