TP53 and pituitary tumor: IRBP-Cre:Rbflox/flox:p53+/− and IRBP-Cre:Rbflox/flox:p53−/− mice developed multiple brain lesions including anterior lobe tumors (63% in IRBP-Cre:Rbflox/flox:p53+/− mice; 15% in IRBP-Cre:Rbflox/flox:p53−/− mice), melanotrope tumors (2%; 0%), pituitary tumors (8%; 0%), PB (15%; 62%), and other unclassified lesions (11%; 85%) [98].