Our study found that Lyc.HCL inhibited ESCC cell proliferation, metastasis, and invasion and shrank tumors in mice by directly downregulating TRIM22, a protein that promotes cancer cell growth and metastasis, and interfering with the JAK2/STAT3 and Erk pathways, which are necessary for cancer cell proliferation. The gene discussed is STAT3; the disease is esophageal squamous cell carcinoma.