JAK2 and esophageal squamous cell carcinoma: Our study found that Lyc.HCL inhibited ESCC cell proliferation, metastasis, and invasion and shrank tumors in mice by directly downregulating TRIM22, a protein that promotes cancer cell growth and metastasis, and interfering with the JAK2/STAT3 and Erk pathways, which are necessary for cancer cell proliferation.