At 3 months of age, human APOE4 induced slightly more differentially expressed proteins (DEPs) than human APOE3 in 5xFAD mice (162 DEPs for E4‐AD vs. E4‐WT comparison and 58 DEPs for E3‐AD vs. E3‐WT comparison) (Figure 3A and Appendix S1). Here, APOE is linked to Alzheimer disease.