AKT1 and Alzheimer disease: In addition to RAS signaling, the PI3K‐AKT signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Rap1 signaling pathway, MAPK signaling pathway, and cGMP‐PKG signaling pathway also stand out in our proteomic analysis, suggesting their potentially important roles in the pathogenesis of APOE4 in AD.